Precious Proteins

There I was; leading a small team of scientists to save these precious proteins for the world. For the future. Ice cream proteins. We had two of these rare proteins that expressed smooth, creamy, flavorful ice cream. And recovered another from an evil group of industrial men. It had been stolen from a collaborator; this one expressed rich butterscotch ice cream.

I had hidden these proteins in a house. But as the private industry group of men were surrounding us, I distributed the three precious proteins to three individuals in our small group (one looked like Albert Einstein). And told them to run. Run, hide; don't let ourselves, and the proteins be caught. Faint, punt, divert those bad men away from each of us. Don't listen to their pleas and lies.

We must preserve and keep these proteins safe. Safe for all to access in the future. Without modifications, without capitalization; free for all mankind. 'Run, and protect them with your lives.' For these are the keys to the Perfect Ice Cream. RUN!!!!

Then there was a small party outside, a gathering of friends to share food and music. Graeme playing guitar (I didn't think he had a music bone in his body), a girl with short blond hair and fine voice, and I thank John and Tracy for coming all the way from Indiana to play bass and share in the celebration. Of ice cream.

Full moon triggers wild and vivid dreams at night.

To mouse, or not to mouse. What is the question?

After many years in medical and veterinary biology and pathology, I always questioned the (rather blind) reliance on the mouse model by modern science. I was glad to see I am not the only one.

Sometimes, there is a 800-pound silverback gorilla in the room and he is 'invisible'. This article exposes the gorilla and shows that the problem animal is not the gorilla but in fact a big fat rodent! An often overlooked aspect of research studies using rodents is that these animals tend to be sedentary, mentally stagnant and overfed. This life style results in obesity and a range of consequent pathologies, including cardiovascular disease, cancer, diabetes, accelerated neurodegeneration and renal failure. This article details the fact that animals in such an unhealthy state do not qualify as appropriate research models for anything other than the study of 'couch potatoes'. 

This is a major wake-up call for the research community and easily addressed by portioned feeding of laboratory rodents and by putting a running wheel in their cages.

Citation: Shelley C, Marshansky V: "Sometimes, there is a 800-pound silverback gorilla in the room and he is..."  Evaluation of: [Martin B et al. "Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A. 2010 Apr 6; 107(14):6127-33; 

doi: 10.1073/pnas.0912955107]. 

Faculty of 1000, 22 Jul 2010. F1000.com/3078978

Climate Changes: Interactive River Flow Map

Climate change cometh. This year (so far) has been one of extreme weather nationwide. Rivers are either flooding or drying up (exemplified here in Texas). The interactive map below is borrowed from Climate Central, a website with reliable information on global climate changes.

Word for Today: June 21, 2011.

Word for Today: thingification. The consideration of an abstraction or an object as if it had living existence and abilities; objectivication in social relations; modern Cartesian science. Reification.

Domestication Experiment with Silver Fox

I've known about Dr. Belyaev's experiment for many years, but this is the first (current) video of the foxes.


The incredible fox domestication experiment in Novosibirsk, Russia from Tyler Cole on Vimeo.

You can read more about Cole's visit to Russia and the Institute by following this link.

An article about domestication of animals, in which the Novosibirsk foxes were featured, appeared in a recent issue National Geographic.

The Zeitgeist Movement

I have no words that can express the relevance and importance of this movie and it's content.

“What You Think, You Become.” Wow! Really? | Secret Life of Scientists & Engineers | PBS

“What You Think, You Become.” Wow! Really? | Secret Life of Scientists & Engineers | PBS

Are we there now?

In The Demon-Haunted World, Carl Sagan wrote:

Science is more than a body of knowledge; it is a way of thinking. I have a foreboding of an America in my children's or grandchildren's time -- when the United States is a service and information economy; when nearly all the key manufacturing industries have slipped away to other countries; when awesome technological powers are in the hands of a very few, and no one representing the public interest can even grasp the issues; when the people have lost the ability to set their own agendas or knowledgeably question those in authority; when, clutching our crystals and nervously consulting our horoscopes, our critical faculties in decline, unable to distinguish between what feels good and what's true, we slide, almost without noticing, back into superstition and darkness.

Pronghorn Declines in Texas

The Pronghorn is one of the iconic mammals of the West in North America. Often referred to as 'antelope,' Antilocapra americana is the sole survivor of twelve species that roamed the North American continent before one of the Great Extinctions (Pleistocene) 10,000-12,000 years ago. (Unlike the pronghorn, true antelopes are a member of the cattle family and are not native to North America. Pronghorns have forked horns; antelopes have unforked horns.) Early observations recounted pronghorns covering the grassy plains. Their traditional range was documented reaching from south-central Canada down into Texas and northern Mexico, and west to Baja, California.

Observations of declines in pronghorn populations were noted in the early 1900's; hunting pressure reduced their population to 13,000 in the 1920's. Disease, especially Blue Tongue, also contributed to reductions. Luckily, conservation efforts helped to restore populations: 500,000 to 1,000,000 across the continent. However, local populations that rebounded have recently declined again. West Texas is one of those areas.

Similar to nationwide trends, overall declines in Texas have paralleled loss of habitat. Only two regions now support pronghorns: the Panhandle and Trans-Pecos areas. The latter has declined faster over the last 150 years, and has recently accelerated. Population fluctuations usually follow changes in water and forage availability, so decreases during years of drought are not surprising. Herds typically rebound by improved reproduction and survival with more favorable weather and food availability, as they did after the drought of the 1990's. However, population estimates of pronghorns in the Trans-Pecos region have continued to decline despite more favorable forage availability during the last three years. In fact, these populations are the lowest since the 1970's. The question is: why?

In 2007, state parks and wildlife officials, hunters, and landowners that profit from hunting licenses began to sit up and take notice of pronghorn populations. Based on preliminary studies and data collection, two hypotheses predominate: internal parasites and predation. The Borderlands Research Institute (BRI) at Sul Ross State University collected a few hundred samples since 2009. They discovered a high load of a common internal stomach parasite, the roundworm, in both hunter-harvested and regional habitat-dwelling animals. A high parasite burden can cause anemia (low red blood cell count), weakening an animal and increasing susceptibility to disease, predation and other stresses. Reproduction can also be affected contributing to decreases on populations. 

Predation is always the favored target of declining populations involving any mammalian species valued by human economics, especially livestock and hunting-target species. Although predators occupy a practical and valuable niche in mammalian ecosystems, large predators have historically served as an easy scapegoat for unexplained deaths. Regardless, considering the overall increasing urban and rural populations of coyotes, investigation into the role of predation on the Texas pronghorn is valid. Although the adult pronghorn can outrun a coyote and cougar, even a cheetah, fawns are more susceptible to predation.

The recruitment into a herd of pronghorn by growing fawns, called 'fawn recruitment,' is commonly a preferred determinant of populations than mortality of adults. This measure more realistically reflects the reproductive capacity of does as well as predation pressure, since they are the typical target by predators: mostly coyotes, cougars, eagles. The major predator of adult pronghorns is Man. 

A 1948-1977 summary of fawn recruitment rates in Canada and the U.S. varied from 43 (fawns per 100 does) in Texas to highs of 105 in South Dakota. More recent pooled data - 1978-2008 - revealed that despite fluctuations in numbers, fawn recruitment continued to decline in most of the same areas as the previous study. The data also revealed differences in fawn recruitment associated with vegetation communities. An independent study of fawn recruitment and forage availability in Arizona showed an increase in fawn recruitment parallel with forage conditions. Their findings strongly suggested that a diversity of plant species is optimal pronghorn habitat and maintenance of habitat diversity is important. This, along with supporting evidence from other independent studies, demonstrates differences in fawn survival may depend on the diets of adults as well as offspring. 

Despite increases in rainfall over the past three years and subsequent increases in forage availability, an important component may be missing: accessibility. The pronghorn display an unusual behavior apart all other wild ungulates: they are not good jumpers. They are disinclined to jump even a low brush fence over three feet high. Small bands of pronghorn have been known to almost starve within a fenced enclosure while plenty of food is available on the outside. When hardpressed, they can jump over moderately high obstructions, but fences will alter their ranges and access to forage. They have been observed to crawl under or between wires of barbed-wire fences, prompting many conservation cooperatives to remove the bottom wire or replace it with a barbless wire. 

The major factor in determining animal populations across the continent during modern times is habitat changes. Land use patterns, including development, resource extraction, and traffic, have changed not only the topographical features but also water and food availability and accessibility. Entire ecosystems are changing. As habitats shrink, many species are competing for the same food and water resources. Migration routes are cut off or severely restricted across the country. Along with habitat changes are subsequent down-stream pressures: increased density of animals and parasite loads, disease exposure, local vegetation exhaustion, decreased vegetation to hide from predators, traffic mortality increases, reductions in reproduction and subsequent offspring survival. Whether these factors have been taken into account in Texas pronghorn performance and survivability is unknown.

Last September the Texas Parks and Wildlife Department (TPWD) awarded a 3 year $111,210 grant to the BRI at Sul Ross State University in Alpine, TX. Their research aims to evaluate the two competing hypotheses described above, regarding pronghorn survival and productivity in the Trans-Pecos area. Meanwhile, the Trans-Pecos Pronghorn Working Group, a group of West Texas landowners, outfitters, TPWD biologists, BRI personnel and wildlife veterinarians, decided to transfer several hundred pronghorn adults from the Texas Panhandle area to West Texas. My objection to this move is that moving healthy animals to locations where populations are inexplicably and rapidly declining is premature and possibly deleterious to the health of the transplanted animals.

Because the decline of the Panhandle pronghorn population appears to be less than that in the Trans-Pecos area, I hope that those involved in this move have considered using the Panhandle population, and others living in similar habitats as those in the Trans-Pecos region, as controls. I also hope that those involved in this research expand their consideration of factors that govern population performance, including population displacement and decline. Rather than address the Trans-Pecos problem from a 'Band-aid' approach, and jeopardizing the lives of transplanted animals at the expense of another population, a thoroughly planned investigation based on scientific principles should precede premature and possibly detrimental short-term fixes.

Other regions have and continue to study and address pronghorn population declines. Several organizations -local, state and federal- are cooperatively working to facilitate habitat preservation. Even migration corridors are being preserved and maintained in several states, such as Montana and southern Canada. Many ranches in Oregon and Arizona are removing unnecessary fence lines and installing barbless wire, especially on bottom lines. Natural gas companies in Wyoming are cooperatively working with organizations to alter gas pads and traffic in order to preserve migration corridors and habitat. Underpasses are being constructed across major highways to divert migration routes away from fences and traffic. Ranches in the upper Great Plains are cooperatively restoring overgrazed ranges for pronghorn forage.

Maybe it is time for Texas to rejoin the Union to help explore and solve its problems. At the very least, they can expand their considerations from a few trees and to the entire forest. Animal populations exist in an interconnected community and system, and problems should be considering holistically. Let's all focus on finding answers to the questions and then examining long-term solutions. 

Pronghorn benefit a huge success; release set for late February

Climate Change Cometh

Loosely following the debate, discourse and arguments surrounding climate change, sometimes I just have to look away. Like watching a bad wreck. A very complex subject, where there are no accurate and reliable models and predictions. The projections fit into a very wide area under the curve and outliers will probably be shifting that range more than not. More than regional, even global, this is a solar system-dependent phenomenon.

Anyone denying climate change during our lifetime is more than ignorant; it is stupidity. I understand that humans do not like change, but to base ignorance in a belief system that climate change is not eminent is truly stupidity. The evidence is not only a well-documented scientific observation, it is an experience at our personal level. The real issues are not if climate change is real, but how much of that change is attributable to anthropogenic causes. 

With any knowledge of geological and geographical history at a middle school level, we know that global and regional climate and weather change. To disbelieve and/or deny that is unacceptable. Supplementing that knowledge with how regional and global climate is influenced by long-term subtle and traumatic events - volcanic explosions, rampant wildfires, asteroid collisions, sunspots, changes in ecosystems, etc - will aid understanding the connections between systems on and above this planet. Now add centuries of human intervention and technological contributions, sometimes rapid, to changes in regional and global-wide systems. To deny anthropogenic impact on our planetary systems is inexcusable.

The question that remains, and which may remain unanswerable, is the degree of human impact. At this point in time, the question may remain moot. The question requiring attention is how we can reduce our impact.

Weather and climate have a long history of cyclic changes, as long as the life of this planet and our solar system. We cannot deny our current climate change. Unfortunately, the politically hot term that is mistakenly embroiled world-wide, 'global warming,' has been misconceived. But the damage is done. Now we must move beyond that and accept that climate change, with possible accompanying extremes of hot and cold weather, is here. We are feeling the impact. Now.

Yet, like little ants, we continue to embroil ourselves in useless arguments and self-serving blame and flame throwing. This gets us nowhere. It's time to discard the disbelief, bottle the self-serving useless tirades, promote more accurate and constructive discourse; it is time to act and prepare ourselves for cooperation and adaptation. Reduce our contributions to climate change and learn to adapt to the global-changing weather patterns as a global community.

I was somewhat encouraged to read on a more-than-useless forum  debate the following intelligent post:

I know many weather and climate factors are the product of non-man based cycles. We cannot stop major long-run Global and Solar cycles, but the sudden changes we are seeing the last 50 years seem to be producing a lot more energy due to how quick the changes are occurring. (aka more instability)

However we do need to recognize that warming is a serious issue -- and one that Man likely cannot stop. But instead of trying to prepare and do what we can to slow it --- We are accelerating it now, and have a whole contingent of Americans that believe we should just ignore it --- which just seems foolish.

Man didn't cause all the European Glaciers to severely melt 4000 years ago. (see what's happened in Africa and the Middle East as all the Glacial-melt-fed Rivers dried up --- It's amazing to try to think of Iraq and Egypt as fertile plains, not dust-bowls.)

So we know climate change is a real threat regardless of Man -- but exacerbating it, certainly seems to be ignorant and foolish, just as much as thinking we can fully control it.

 Let's put aside our ignorance, our self-serving demonstrations, and join as a community to reduce human impact and adapt to the coming changes.