Precambrian on the brain

Spent a few hours living in the past during visit to Museum of the Earth (Ithaca, NY).

Did a sketch on the progression of the Precambrian period which is rarely represented to any extent in museums.

Which is weird because that is when life first appeared. Sure, it didn't have the fantastic creatures that started appearing in the Cambrian Radiation (I don't use the more common 'Explosion' because it insinuates all life magically happened in an instant). But to me it is more intriguing. Partly because we know less about it.

Yet, we do know that what we consider life first began before oxygen filled our atmosphere. Life then was anaerobic: without oxygen. And appeared only in water, not surprising since the planet was mostly covered with water back then. Water is H2O (hydrogen dioxide), but the two hydrogen atoms are tightly held on to the oxygen. So there was little oxygen in our atmosphere (which was then water vapor, methane, and ammonia).

Bacteria, and their appearance, is what we call the first 'life'. The cog in the wheel is that it depends on how we define 'life', but that's another long topic (which is embroiled in debate within the scientific community). Finding fossils of bacteria have been difficult: partly because they are so small, and partly that most of the rocks from that time period are also rare.

Our planet formed 4.6 billion years ago; a ball of gas, water vapor and hot molten minerals. The planet cooled enough for water to appear ~4.4 bya and cover the planet. A mineral crust began forming ~4.04 bya (called the Hadean eon) and the earliest fossils found are dated 3.5 bya.

Between that time (4.2-3.5 bya) the fist single cells formed. The Last Universal Common Ancestral (LUCA) cell population from which all subsequent life forms descended is estimated to be 3.5 bya. This is estimated from genome compilation (which implies that genes had to be present!).

But! before then was a first universal common ancestor (FUCA). A non-cellular entity is proposed that was the earliest organism with a genetic code capable of performing biological translation of RNA molecules to protein formation through peptides synthesis. In other words, it had to contain enough information to copy itself and evolve. Well, how did that come about?

And that is where my keen fascination is ignited. Hence, my interest in the Precambrian period. But all this is also absent from the museums. However, a few hypotheses are tossed around and debated on the process of how life originated. Yet, if we restrict it to the conventional definition (really a perspective) of life, it excludes possible candidates that were integral in that process.

I'm following two scientists active in this search: biochemist Nick Lane and astrophysicist Sara Imari Walker. They think outside the box. But more on that later. 

Living in an area under the curve

Being neurodivergent is sometimes like being a data point on a normal area under the curve. That especially becomes apparent when navigating society, including health care, insurance, and public policy. Our current state of the US is a perfect example where an outlier on that curve is a target for ridicule, harassment, or a political object. It all complicates understanding and interacting with each other. 

To aid navigation through life and society we want to understand ourselves, be understood by others, and accepted for who we are. We usually seek guidance in the first step, which is often thorny:

"Occasionally I wonder what my life would be like if a doctor had ever actually settled on "You are THIS type of neurospicy". I've had, in my life, three attempts at diagnosis, and it's always "You're not quite [thing], but have aspects of it."

My take on this (with help from a neurodivergent neuroscientist/psychologist colleague) follows: the brain is 'plastic', which means it functions in a myriad of ways to enact with & survive in its environment. And no two minds are alike.

Humans like 'boxes' into which they place and label animate and inanimate things. It helps us understand and communicate with others. Medical and insurance communities require and assign labels as guides to categorize physical/mental states and to navigate social systems: care, policy, education, etc. But they do not fully represent the reality.

Each category (box) has a probability of a standard normal distribution (area under the curve), which is agreed upon by a community of practitioners and researchers. For mental states and function the official guide is the DSM. It is not accurately representative of the full diversity of mental function because its goal is to determine 'normal' & 'pathology' (or 'outliers', if you will). What determines 'normal' is that middle area under the curve (AUC), but is also a biased interpretation (socially constructed). Humans are complicated. 

Thus 'diagnoses' (which I don't like because it implies pathology) are attempts to categorize and put labels on the way your brain functions. But they don't fully capture the reality. Boundaries of those categories are fluid, often unspecific and flow into another. A good discussion and graphic for autism is addressed in this recent article.

Increasing opinion by practitioners & researchers is that other neurodiverse traits currently excluded be added to the Autism Spectrum Disorder (ASD) category: ADHD, bi-polar, anxiety disorder, etc. All these can co-exist, should be recognized & included in a diagnosis. Or minimally be included in ongoing discussion with each practitioner and client.

I was told when learning my 'label' and category (2007) that my primary traits aligned with autism, specifically 'Asperger's syndrome'. I also fit the criteria of "mild" ADHD. However, medically and legally, I could not be both. According to the DSM-4, my category had to be one or the other. (see footnote below)

As my colleague explained both autism and ADHD can co-occur regardless of the strict criteria and categorization in the DMS-4. If I wanted his analysis added to my medical records, it would be 'Asperger's Syndrome'. (I chose not to have it documented for reasons explained in an earlier post.) 

Research in the last two years indicate that a significant percentage of people with ASD also exhibit symptoms of ADHD, and vice versa. The overlap is more inclusive of the reality of traits and function. Yet it can complicate diagnosis and therapy. Both conditions share some behavioral or cognitive characteristics but can also have distinct features.

Regardless of a diagnosis label, individuals can discover more about themselves and other neurodivergents through conversations sharing experiences and testimony. It's less about what label you are than more about who you are as a person. The best way is to meet other ND people and learn from each other. 
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Note: A newer addition, DSM-5, eliminated the Asperger's label and incorporated those criteria into the Autism Spectrum Disorder category. Also, DSM-5 allows for the co-diagnosis of ASD and ADHD conditions, but the current colloquial term AuDHD is not included.